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KMID : 0616120170480020108
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 2 p.108 ~ p.112
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Triterpenes with Inhibitory Effects of Nitric Oxide Production from the Fruit Galls of Actinidia polygama on LPS-Induced RAW264.7 and BV2 Cells
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Li Xiao Jun
Kim Kwan-Woo
Ko Won-Min
Kim Dong-Cheol
Yoon Chi-Su
Liu Xiang Qian
Oh Hyun-Cheol
Kim Youn-Chul
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Abstract
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To isolate and identify the constituents of the fruit galls of Actinidium polygama as well as evaluate the anti-inflammatory effects of the isolated compounds, a total of five triterpenes were isolated including 2α,3α,24-trihydroxy-12-ursene-23-al-28-oic acid (1), corosolic acid (2), 2α,3α,24-trihydroxyurs-12,20(30)-dien-28-oic acid (3), 2α,3α,24-trihydroxyolean-12-en-28-oic acid (4), and 2α,3α,24-trihydroxyurs-12-en-28-oic acid (pygenic acid B) (5). Compounds 1, 3, and 4 were isolated from the fruit galls of A. polygama for the first time. Compound 3 decreased NO production in LPS-stimulated RAW264.7 macrophages and mouse microglia BV2 cells in a concentration-dependent manner.
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KEYWORD
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Actinidium polygama, Triterpene, Anti-inflammation, Nitric oxide, RAW264.7, Microglia BV2 cell
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